Raised in the African bush country by her zoologist parents, Cady Heron thinks she knows all about the 'survival of the fittest'. But the law of the jungle takes on a whole new meaning when the home-schooled 16-year old enters public high school for the first time. Trying to find her place between jocks, mathletes, and other subcultures, Cady crosses paths with the meanest species of all - the Queen Bee, aka the cool and calculating Regina George, leader of the school's most fashionable clique, the Plastics. When Cady falls for Regina's ex-boyfriend Aaron Samuels, though, the Queen Bee is stung - and she schemes to destroy Cady's social future. Cady's own claws soon come out as she leaps into a hilarious 'Girl World' war that has the whole school running for cover.